Amantadine → HCID 70569991, compound

HRID 1414077Notes

Reaction equation

HRID 1414077 reaction equation
[C:1]12([NH2:11])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[Br:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][C:22]=1[Br:23])[N:19]=[C:18]([C:24]([OH:26])=[O:25])[C:17](=[O:27])[NH:16]2.CC12CC3CC(CC(N)(C3)C1)C2>>[C:1]12([NH2:11])[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH2:2]1)[CH2:10]2.[Br:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][C:22]=1[Br:23])[N:19]=[C:18]([C:24]([OH:26])=[O:25])[C:17](=[O:27])[NH:16]2

Participants

4

Reactant 3

HCID 2130AmantadineHCID 30101281-AMINOADAMATANE, 3-METHYLHCID 20289894HCID 20289894, compound

Product 1

HCID 70569991HCID 70569991, compound

Procedure

Following the above procedure, but substituting 3-methyl-1-adamantylamine for 1-adamantylamine, there was prepared a salt of 6,7-dibromo-3,4-dihydro-3-oxo-2-quinoxaline carboxylic acid and 3-methyl-1-adamantylamine. The crystalline product was isolated by filtration and dried; melting point=280°-282° C. with decomposition.

Workup

  1. customThe crystalline product was isolated by filtration
  2. customdried

Sources & evidence

ORD record
ord-94e225098f2148d1b2c08290d69fc0f6
Source dataset
uspto-grants-1981_02
Patent number
US04252954

Reaction notes

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