1,3-Diethyl 2-oxopropanedioate → HCID 13014080, compound

HRID 1414083Notes

Reaction equation

HRID 1414083 reaction equation
[I:1][C:2]1[C:7]([I:8])=[CH:6][C:5]([NH2:9])=[C:4]([NH2:10])[CH:3]=1.O=[C:12]([C:18](OCC)=[O:19])[C:13]([O:15][CH2:16][CH3:17])=[O:14]>C(O)C>[I:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[I:8])[N:9]=[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:18](=[O:19])[NH:10]2

Participants

4

Reactant 2

HCID 691051,3-Diethyl 2-oxopropanedioateHCID 116101834,5-DIIODO-BENZENE-1,2-DIAMINE

Product 1

HCID 13014080HCID 13014080, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution was prepared from 0.9 g. of 4,5-di-iodo-o-phenylenediamine and 25 ml. of ethanol. Five grams of diethyl ketomalonate were added and the resulting mixture was heated to refluxing temperature with stirring overnight. The reaction mixture was then cooled. Ethyl 6,7-di-iodo-3,4-dihydro-3-oxo-2-quinoxaline carboxylate formed in the above reaction precipitated and was collected by filtration; yield=0.8 g.; mp=275°-276° C.

Workup

  1. customA solution was prepared from 0.9 g
  2. temperaturethe resulting mixture was heated
  3. temperatureto refluxing temperature
  4. temperatureThe reaction mixture was then cooled

Sources & evidence

ORD record
ord-70f1858d900e4669bac86a2bb6d3ae83
Source dataset
uspto-grants-1981_02
Patent number
US04252954

Reaction notes

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