1,3-Diethyl 2-oxopropanedioate → HCID 70549630, compound

HRID 1414085Notes

Reaction equation

HRID 1414085 reaction equation
BrC1C(Br)=CC(N)=C(N)C=1.O=C(C(OCC)=O)C(OCC)=O.[Br:23][C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][C:33]=1[Br:34])[N:30]=[C:29]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[C:28](=[O:40])[NH:27]2>C(O)C>[Br:23][C:24]1[C:33]([Br:34])=[CH:32][C:31]2[C:26](=[N:27][C:28](=[O:40])[CH:29]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[N:30]=2)[CH:25]=1

Participants

5

Reactant 3

HCID 691051,3-Diethyl 2-oxopropanedioateHCID 6320219HCID 6320219, compoundHCID 121969444,5-Dibromobenzene-1,2-diamine

Product 1

HCID 70549630HCID 70549630, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4,5-Dibromo-o-phenylenediamine was cyclized to the corresponding quinoxaline carboxylic acid ester by the procedure of Preparation 1 utilizing 4.1 g. of the diamine and 2.7 g. of diethyl ketomalonate in 75 ml. of anhydrous ethanol. Ethyl 6,7-dibromo-3,4-dihydro-3-oxo-2-quinoxaline carboxylate thus prepared melted at 235°-236° C. (yield=3.9 g.).

Sources & evidence

ORD record
ord-a84ec79716ee4c43bcde6aea1cca84e2
Source dataset
uspto-grants-1981_02
Patent number
US04252954

Reaction notes

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