Ammonia → HCID 178456690, compound

Participants

Reaction Steps

A preferred embodiment of the improved process according to the present invention comprises reacting 1-isopropyl-1-cyanohydrazine in the form of a 6-8 percent solution in tetrahydrofuran with phosgene at a temperature of between 0°-30° C., treating the reaction mixture with anhydrous ammonia to form the ammonium salt of 1-isopropyl-3-hydroxy-5-chloro-1,2,4-triazole, which precipitates almost totally from the tetrahydrofuran reaction mass, and liberating from said isolated salt 1-isopropyl-3-hydroxy-5-chloro-1,2,4-triazole in a yield ranging from 85.8-92.1% of theory and in a very pure state, such as of 98% assay, by treating it with 32-37% hydrochloric acid.

Provenance & Evidence