反应详情

温度

110 °C

182 Parts of 4-methoxyphenyl-thiourea are suspended in 900 parts of toluene; 310 parts of thionyl chloride are added over a period of 1 hour at 20° to 30° C. The temperature of the mixture is then uniformly raised to 110° C. within 2 hours while stirring, stirring is continued for 2 hours under reflux, 20 parts of kieselguhr are added and the toluene is distilled off by blowing in steam. The solution of 6-methoxy-2-aminobenzthiazole hydrochloride obtained is clarified by adding 5 parts of charcoal, filtered and the clear filtrate is added to 175 parts of 25% aqueous ammonia solution.

1. stirringstirring
2. temperatureunder reflux
3. addition20 parts of kieselguhr are added
4. distillationthe toluene is distilled off