HCID 70633320, compound → HCID 70632869, compound

HRID 1414179Notes

Reaction equation

HRID 1414179 reaction equation
C(OC([CH:8]([NH2:33])[CH2:9][C:10]([N:12]1[C:16](=[O:17])[CH2:15][N:14]([N:18]=[CH:19][C:20]2[O:24][C:23]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)=[CH:22][CH:21]=2)[C:13]1=[O:32])=[O:11])=O)(C)(C)C>Cl.C(O)(=O)C>[ClH:31].[NH2:33][CH2:8][CH2:9][C:10]([N:12]1[C:16](=[O:17])[CH2:15][N:14]([N:18]=[CH:19][C:20]2[O:24][C:23]([C:25]3[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=3)=[CH:22][CH:21]=2)[C:13]1=[O:32])=[O:11]

Participants

3

Reactant 1

HCID 70633320HCID 70633320, compound

Product 1

HCID 70632869HCID 70632869, compound

Reagents, catalysts & solvents 1

HCID 22641269Acetate-hydrochloric acidSolvent

Procedure

The 3-(t-butoxycarbonyl-aminopropionyl)-1-{[5-(4-chlorophenyl) furfurylidene]amino}hydantoin (47 g, 0.11 mole) was added to 3% hydrochloric acid/acetic acid (500 ml) and was stirred for 2 hours. The mixture was filtered and the collected solid was washed with nitromethane and ether which yielded 30.5 g (82% overall), m.p. 242°-245°.

Workup

  1. filtrationThe mixture was filtered
  2. washthe collected solid was washed with nitromethane and ether which
  3. customyielded 30.5 g (82% overall), m.p. 242°-245°

Sources & evidence

ORD record
ord-f7b7fdab16dc441e9211bdb028538f84
Source dataset
uspto-grants-1977_01
Patent number
US04001222

Reaction notes

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