HCID 70633489, compound → HCID 70632822, compound

HRID 1414180Notes

Reaction equation

HRID 1414180 reaction equation
C(OC([NH:8][CH:9]([CH3:34])[C:10]([N:12]1[C:16](=[O:17])[CH2:15][N:14]([N:18]=[CH:19][C:20]2[O:24][C:23]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[C:27]([Cl:32])[CH:26]=3)=[CH:22][CH:21]=2)[C:13]1=[O:33])=[O:11])=O)(C)(C)C.Cl.CC(OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=O>>[ClH:31].[NH2:8][CH:9]([CH3:34])[C:10]([N:12]1[C:16](=[O:17])[CH2:15][N:14]([N:18]=[CH:19][C:20]2[O:24][C:23]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[C:27]([Cl:32])[CH:26]=3)=[CH:22][CH:21]=2)[C:13]1=[O:33])=[O:11]

Participants

3

Reactant 2

HCID 70633489HCID 70633489, compoundHCID 131710585HCID 131710585, compound

Product 1

HCID 70632822HCID 70632822, compound

Procedure

The 3-[2-(t-butoxycarbonyl-amino)propionyl]-1-{[5-(3,4-dichlorophenyl)furfurylidene]amino}hydantoin (15.1 g, 0.033 mole) was added to 3% hydrochloric acid/acetic (185 ml) and was stirred for 2 hours. The mixture was filtered and the collected solid was washed with nitromethane and ether which yielded 10.4 g (70%, 25% overall), m.p. 192°-196°.

Workup

  1. filtrationThe mixture was filtered
  2. washthe collected solid was washed with nitromethane and ether which
  3. customyielded 10.4 g (70%, 25% overall), m.p. 192°-196°

Sources & evidence

ORD record
ord-cadaff2aee4f48e092ab8c11355572b5
Source dataset
uspto-grants-1977_01
Patent number
US04001222

Reaction notes

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