HCID 70633022, compound → HCID 70633030, compound

HRID 1414182Notes

Reaction equation

HRID 1414182 reaction equation
C(OC([CH:8]([NH2:37])[CH2:9][CH2:10][CH2:11][CH2:12][C:13]([N:15]1[C:19](=[O:20])[CH2:18][N:17]([N:21]=[CH:22][C:23]2[O:27][C:26]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[C:30]([Cl:35])[CH:29]=3)=[CH:25][CH:24]=2)[C:16]1=[O:36])=[O:14])=O)(C)(C)C>Cl.C(O)(=O)C>[ClH:34].[NH2:37][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([N:15]1[C:19](=[O:20])[CH2:18][N:17]([N:21]=[CH:22][C:23]2[O:27][C:26]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[C:30]([Cl:35])[CH:29]=3)=[CH:25][CH:24]=2)[C:16]1=[O:36])=[O:14]

Participants

3

Reactant 1

HCID 70633022HCID 70633022, compound

Product 1

HCID 70633030HCID 70633030, compound

Reagents, catalysts & solvents 1

HCID 22641269Acetate-hydrochloric acidSolvent

Procedure

The 3(t-butoxycarbonyl-aminohexanoyl)-1-{[5-(3,4-dichlorophenyl)furfurylidene]amino}hydantoin (29 g, 0.052 mole) was added to 3% hydrochloric acid/acetic acid (650 ml) and stirred for 2 hours. The mixture was filtered and the collected solid was washed with nitromethane and ether, then heated to boiling in nitromethane and filtered again, yielding 10 g (38%, 28% overall), m.p. 205°-207°.

Workup

  1. filtrationThe mixture was filtered
  2. washthe collected solid was washed with nitromethane and ether
  3. temperatureheated
  4. filtrationfiltered again
  5. customyielding 10 g (38%, 28% overall), m.p. 205°-207°

Sources & evidence

ORD record
ord-661a577048cb4a01a8f3988aed46ddde
Source dataset
uspto-grants-1977_01
Patent number
US04001222

Reaction notes

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