4-Aminobenzoic Acid → 4-[(cyclobutylcarbonyl)amino]benzoic acid

HRID 1414185Notes

Reaction equation

[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[CH:11]1([C:15](Cl)=[O:16])[CH2:14][CH2:13][CH2:12]1>>[CH:11]1([C:15]([NH:1][C:2]2[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=2)=[O:16])[CH2:14][CH2:13][CH2:12]1

Participants

Reactant 2

HCID 9784-Aminobenzoic Acid

HCID 78705Cyclobutanecarbonyl chloride

Product 1

HCID 42303324-[(cyclobutylcarbonyl)amino]benzoic acid

Procedure

4-Cyclobutanecarbonylamino-benzoic acid was prepared as described in Example 3 from 7.05 g (0.0514 mol) of p-aminobenzoic acid (PAB) and 6.4 g (0.054 mol) of cyclobutanecarboxylic acid chloride.

Sources & evidence

ORD record: ord-7ef4e2cebced45fda0f51eddcb62007e
Source dataset: uspto-grants-1977_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04001218

Reaction notes

Loading…