Tetrahydrofuran → HCID 54415633, compound

Participants

Reaction Conditions

Reaction Steps

To 20 ml of tetrahydrofuran, 1 g of N-(1-adamantane carbonyl)-N' -cinnamoyl piperazine which was obtained in Example 1 (II) was dissolved and to this 0.24 g of lithium aluminum hydride powder were added gradually at 0° C. After refluxing for 4 hrs., it was cooled to 0° C and water was added to this at 0° C carefully to separate an organic solvent layer, subsequently the solvent was distilled away. The residues were dissolved in chloroform which was washed with water, dehydrated and then was distilled away. The residues were subjected to silica gel column chromatography (eluant: mixture of chloroform and methanol) and N-(1-adamantyl methyl)-N'-cinnamyl piperazine was obtained. Melting point of the product was 85°-87° C and the yield was 20%.

Provenance & Evidence