反应详情

To a boiling suspension of 160 ml. of methyl ethyl ketone containing 23.0 g. (0.165 mole) of methenamine is slowly added a hot suspension of 25 g. (0.16 mole) of l-mandelate acid in 60 ml. of methyl ethyl ketone. The heat source is removed. The solution is stirred to room temperature, then cooled in an ice-water bath. White crystals are collected by filtration, washed with a small amount of cold methyl ethyl ketone, followed by anhydrous ether, and dried at 50° C. in vacuum for 4.5 hours to obtain methenamine levo-mandelate. mp. 133.5°-135.5° C [α]D20 -63.3° (C = 3,H2O)

1. additionTo a boiling suspension of 160 ml
2. additiona hot suspension of 25 g
3. customThe heat source is removed
4. temperaturecooled in an ice-water bath
5. filtrationWhite crystals are collected by filtration
6. washwashed with a small amount of cold methyl ethyl ketone
7. customdried at 50° C. in vacuum for 4.5 hours