Phosphorus tribromide → 2-Bromobenzyl bromide

To 187.0 g of o-bromobenzyl alcohol at room temperature, with stirring, is added dropwise, 271.0 g of phosphorus tribromide. After the addition is complete, stirring is continued for three hours at room temperature. The mixture is then heated at 90°-100° for 3 hours and poured into 6 kg of crushed ice. The hydrolysis mixture is extracted with three 600 ml portions of ether, the ether extracts are washed, dried, and concentrated to give o-bromobenzyl bromide, bp. about 130°-132° (15mm).

1. additionis added dropwise
2. additionAfter the addition
3. temperatureThe mixture is then heated at 90°-100° for 3 hours
4. extractionThe hydrolysis mixture is extracted with three 600 ml portions of ether
5. washthe ether extracts are washed
6. customdried
7. concentrationconcentrated

ORD record

ord-e5a1b1172e224284b62b2440a0afc0d2

Source dataset

uspto-grants-1977_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04001233