Potassium Hydroxide → HCID 23690025, compound

HRID 1414232Notes

Reaction equation

HRID 1414232 reaction equation
[CH3:1][S:2][C:3]1[O:7][C:6]([C:8]([O:10]CC)=[O:9])=[N:5][N:4]=1.[OH-].[K+:14]>C(O)C>[CH3:1][S:2][C:3]1[O:7][C:6]([C:8]([O-:10])=[O:9])=[N:5][N:4]=1.[K+:14]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 21486850Ethyl 5-(methylsulfanyl)-1,3,4-oxadiazole-2-carboxylate

Product 1

HCID 23690025HCID 23690025, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 5-methylthio-1,3,4-oxadiazole-2-carboxylate (4.31 g., 0.023 mole) in absolute ethanol (50 ml.) was treated dropwise with 2.87 g. (0.023 mole) of 45 wt.% potassium hydroxide solution. The resultant white precipitate was isolated by filtration, washed with ethanol and dried to yield 3.92 g. (86%) of the title compound; M.P. 176°-177° C. with decomposition after recrystallization from ethanol.

Workup

  1. customThe resultant white precipitate was isolated by filtration
  2. washwashed with ethanol
  3. customdried
  4. customto yield 3.92 g

Sources & evidence

ORD record
ord-c811e000aa774a96b3bd96e79eca5545
Source dataset
uspto-grants-1977_01
Patent number
US04001238

Reaction notes

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