HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1414252Generated: November 2, 2026
Sodium Cyanide → (Pyrimidin-2-yl)acetonitrile
https://huagongshe.com/reaction/1414252
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 2-(Chloromethyl)pyrimidine | HCID 12877371 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (Pyrimidin-2-yl)acetonitrile | HCID 15264944 | — |
Reaction Steps
A solution of 6.8 g. of 2-(chloromethyl)pyrimidine is added dropwise to a solution of 5.2 g. of sodium cyanide in 100 ml. of dimethylsulfoxide. The mixture is heated at 50° C. for 2 hours, then diluted with 150 ml. of 5% aqueous sodium carbonate solution and extracted with ether. The extract is dried and concentrated to give 2-(2-pyrimidyl)acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04001241 |
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| Source dataset | uspto-grants-1977_01 |
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| ORD ID | ord-3b5775942b69419fb71b03e6d0a322d2 |
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| Source note | uspto-grants-1977_01 |
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