Dimethylamine → HCID 21486904, compound

HRID 1414256Notes

Reaction equation

HRID 1414256 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([O-:10])=O.[CH3:11][NH:12][CH3:13].[CH2:14]([OH:16])C>>[CH3:14][O:16][CH:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:8]([N:12]([CH3:13])[CH3:11])=[O:10]

Participants

4

Reactant 3

HCID 674DimethylamineHCID 702EthanolHCID 69315582-Pyridylacetate

Product 1

HCID 21486904HCID 21486904, compound

Procedure

A mixture of 18.1 g. of methyl 2-methoxy-2-(2-pyridylacetate and 10 g. of dimethylamine in ethanol is stirred at room temperature for 26 hours. The mixture is concentrated, dissolved in chloroform and extracted with brine. The organic phase is dried over magnesium sulfate and filtered and the solvent is removed under reduced pressure to give 2-methoxy-N,N-dimethyl-2-(2-pyridyl)acetamide.

Workup

  1. additionA mixture of 18.1 g
  2. concentrationThe mixture is concentrated
  3. dissolutiondissolved in chloroform
  4. extractionextracted with brine
  5. dry with materialThe organic phase is dried over magnesium sulfate
  6. filtrationfiltered
  7. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-b82a45d711a04f799b71095365eda031
Source dataset
uspto-grants-1977_01
Patent number
US04001241

Reaction notes

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