Hydrazine → HCID 68122226, compound

HRID 1414321Notes

Reaction equation

HRID 1414321 reaction equation
[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16](OCC)=[O:17])[C:11]2=[O:15])[CH:7]([CH3:21])[CH2:6][CH2:5][C:4]=3[CH:3]=1.[NH2:22][NH2:23]>CO>[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16]([NH:22][NH2:23])=[O:17])[C:11]2=[O:15])[CH:7]([CH3:21])[CH2:6][CH2:5][C:4]=3[CH:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 15518014HCID 15518014, compound

Product 1

HCID 68122226HCID 68122226, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylate (10 g., 0.0347 mole) is dissolved in methanol (200 ml.) containing 25 ml. of 97 percent hydrazine. The mixture is warmed to accelerate solution. The solution is stirred at room temperature, and solid begins to separate immediately. The solid is separated by filtration, washed with methanol and recrystallized from aqueous ethanol to provide 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid hydrazide, m.p. 236-238° C.

Workup

  1. additioncontaining 25 ml
  2. temperatureThe mixture is warmed
  3. customto separate immediately
  4. customThe solid is separated by filtration
  5. washwashed with methanol
  6. customrecrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-ca910b4c96684f8e875b6d03574048f7
Source dataset
uspto-grants-1977_01
Patent number
US04001243

Reaction notes

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