Dimethylformamide → HCID 14357896, compound

Participants

Reaction Steps

In the manner given in Example 1, 6.844 (20 mmol) of 2-methyl-8-chloro-6-(o-chlorophenyl)-4H-imidazo[1,2-a]-[1,4]benzodiazepine is treated with 40.0 mmol of dimethylmethylene ammonium chloride in dimethylformamide during 2 hours at 100° C. The reaction mixture is quenched on ice, neutralized with 10% aqueous sodium hydroxide and chromatographed over silica gel with 1 l. fractions of 3% methanol/97% chloroform solutions to give 1-(dimethylamino)methyl-2-methyl-8-chloro-6-(o-chlorophenyl)-4H-imidazo[1,2-a][1,4]benzodiazepine of melting point 191°-194° C.

Provenance & Evidence