Sodium Carbonate → HCID 23690030, compound

HRID 1414390Notes

Reaction equation

HRID 1414390 reaction equation
[NH2:1][C:2]1[CH:27]=[CH:26][C:5]([O:6][CH2:7][CH2:8][O:9][C:10]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:11]=2[C:12](=[O:25])[CH:13]=[C:14]([C:20]([O:22]CC)=[O:21])[O:15]3)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+:32].[Na+]>C(O)C>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH2:8][O:9][C:10]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:11]=2[C:12](=[O:25])[CH:13]=[C:14]([C:20]([O-:22])=[O:21])[O:15]3)=[CH:26][CH:27]=1.[Na+:32]

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 12774535HCID 12774535, compound

Product 1

HCID 23690030HCID 23690030, compoundYield 204.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 5-[2-(4-aminophenoxy)ethoxy]chromone-2-carboxylate (3.4g.) in 95% ethanol (250ml.) was boiled, to which was added at once an aqueous solution (20ml.) of sodium carbonate (0.5g.) under heating. The resultant mixture was refluxed for 2 hours. After cooling, the ethanol was evaporated under reduced pressure. The residue was recrystallized from 80% aqueous ethanol to give brown scaly crystals (3.5g.) of sodium 5-[2-(4-aminophenoxy)ethoxy]chromone-2-carboxylate.

Workup

  1. temperatureunder heating
  2. temperatureAfter cooling
  3. customthe ethanol was evaporated under reduced pressure
  4. customThe residue was recrystallized from 80% aqueous ethanol

Sources & evidence

ORD record
ord-97399289de60493cbc4a5152c3d56e4e
Source dataset
uspto-grants-1977_01
Patent number
US04001280

Reaction notes

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