Ethyl Acetate → HCID 12853016, compound

Participants

Reaction Steps

1-methylpiperazine (4.5g.) was added dropwise to a suspension of 5-(2-ethoxyethoxy)chromone-2-carboxylic acid (5.0g.) in chloroform (50ml.). A solution of phosphorus tribromide (2.0g.) in chloroform (10ml.) was added dropwise to the resultant mixture under ice cooling for 10 minutes. The mixture was stirred under ice cooling for 2 hours and at room temperature for additional 1 hour, and then ethyl acetate (250ml.) was added to the reaction mixture. The mixture was washed twice with 5% aqueous solution of sodium bicarbonate and with water in turn, and dried. The solvent was distilled off under reduced pressure to give 2-(4-methyl-1-piperazinyl)carbonyl-5-(2-ethoxyethoxy) chromone (500mg.). The product was derived in the usual manner to its maleate.

Provenance & Evidence