Phenol → HCID 21487310, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 251 g of 2,4-dichloro-5-sulfamoyl-benzonitrile (1.0 mol), 400 ml of dimethylformamide, 200 g of phenol and 80 g of sodium hydroxide was stirred for 3 hours at 130° C. The mixture was then allowed to cool to about 90° C and when its viscosity was low and it was turbid from precipitated NaCl, it was introduced into 10 l of water. After having been allowed to stand for 1 hour at room temperature, the light grey crystallized precipitate was suction-filtered, washed several times with water, and the product still moist after filtration was then recrystallized from isopropanol. The product was first dried in the air and then on a steam bath until its weight remained constant. The colorless crystals thus obtained still contained one mol-equivalent of isopropanol.

Provenance & Evidence