Hydrochloric Acid → HCID 12274618, compound

Participants

Reaction Conditions

Reaction Steps

43 g (1.0 mol) of the 2,4-diphenoxy-5-sulfamoyl-benzoic acid prepared according to (d) were stirred for 4 hours under nitrogen at 135° C with 90 ml of freshly distilled furfurylamine. The faintly yellow reaction solution, which had been cooled to about 80° C, was then introduced while stirring into 1 l of 10 % acetic acid, and the pH of the mixture was then adjusted to 3 by means of 5N HCl. After standing for a short time at room temperature, the N-(2-furylmethyl)-4-phenoxy-5-sulfamoyl-anthranilic acid which had precipitated in crystals was suction-filtered, washed with water and ethanol and dried on a steam bath.

Provenance & Evidence