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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1414421Generated: October 29, 2026

1,3-Cyclohexanedione → HCID 86734361, compound

https://huagongshe.com/reaction/1414421

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-CyclohexanedioneHCID 10434—
Reactantm-FormylbenzonitrileHCID 90670—
ReactantCarbamimidoyl-acetic acid ethyl esterHCID 4599837—
ReactantN,N-dimethylformamide ethanolHCID 19794673—
SolventEthanolHCID 702—
ProductHCID 86734361HCID 8673436156%

Reaction Steps

Heating a solution of 6.5 g of 3-cyanobenzaldehyde, 5.6 g of cyclohexane-1,3-dione and 6.5 g of amidinoacetic acid ethyl ester in 100 ml of ethanol for 6 hours yields 2-amino-4-((3-cyanophenyl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester of melting point 262°C (ethanol/dimethylformamide).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04001258
Source datasetuspto-grants-1977_01
ORD IDord-dd0cbd2c7c32437e83fffc5448edbf53
Source noteuspto-grants-1977_01