Propanoic acid, 2-methyl-3-oxo-, methyl ester → HCID 53839743, compound
Reaction equation
[CH3:1][CH:2]([CH2:7][CH3:8])[CH:3](O)[CH:4]=[CH2:5].C[O:10][C:11](=O)[CH:12](C=O)[CH3:13]>>[CH3:13][CH:12]([CH2:5][CH:4]=[CH:3][CH:2]([CH3:1])[CH2:7][CH3:8])[CH:11]=[O:10]Participants
3
Procedure
57 g (0.5 mole) of 4-methyl-hex-1-en-3-ol and 70 g of α-formylpropionic acid methyl ester (0.6 mole) are heated at from 140° to 200° C whilst stirring; at the same time the methanol liberated is distilled off through a 20 cm column and the carbon dioxide is measured using a gas flow meter. 11.5 liters of carbon dioxide are liberated in the course of three hours. When the elimination of methanol and carbon dioxide has ceased, the mixture is fractionated. 58 g of the above aldehyde (yield: 75% of theory) are obtained. B.p. = 75° - 80° C at 11 mm Hg.
Workup
- distillationat the same time the methanol liberated is distilled off through a 20 cm column
- customare liberated in the course of three hours
Sources & evidence
- ORD record
- ord-bf6c5d466a1f44208e00480306233c46
- Source dataset
- uspto-grants-1977_01
- Patent number
- US04001336
Reaction notes
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