Methyl Chloride → 1-Methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

Participants

Reaction Steps

Starting from 1-phenyl 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5benzodiazepine, obtained in the example VIII, by acting methyl chloride in the presence of sodium ethanolate, there is obtained 1-phenyl 5-methyl 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine, melting at 144°-146° C after recrystallisation in isopropanol. Analysis: C16H14N2O2Calculated: C % 72.16; H % 5.30; N % 10.52; Found: 72.31; 5.51; 10.51.

Provenance & Evidence