HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromopropane → 1-phenyl 5-propyl 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromopropane | HCID 7840 | — |
| Reactant | Iodide Ion | HCID 30165 | — |
| Reactant | Desmethylclobazam | HCID 89657 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Product | 1-phenyl 5-propyl 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine | HCID 21487694 | — |
Reaction Steps
In the same manner by acting propyl bromide or iodide in the presence of sodium ethylate, starting from 1-phenyl 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine, there is obtained 1-phenyl 5-propyl 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine (R1 = H, R2 = Cl, R3 =C3H7, R4 = C6H5) melting at 192°-194° C upon recrystallisation in ethanol. Analysis: c18H17ClN2O2 ; Calculated: C % 65.75; H % 5.21; N % 8.52; Found : 65.66; 5.17; 8.60.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04001408 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-f1f8565d233a4ac89f768191a21afab8 |
| Source note | uspto-grants-1977_01 |