Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 21487768 | HCID 21487768 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 21487777 | HCID 21487777 | — |
Reaction Steps
20 parts of potassium carbonate in 25 parts of water is added to a solution of 16.9 parts of 2-chloronicotinic acid-N-hydroxy-N-cyclohexylamide in 50 parts of dioxane. At 45° C, 12.6 parts of dimethyl sulfate is dripped into the reaction solution and the whole stirred for 30 minutes at 45° C. The reaction product is precipitated by the addition of water. Crystallization from a mixture of benzene and ligroin yields 14.8 parts of 2-chloronicotinic acid-N-cyclohexyl-N-methoxyamide, m.p.: 96° to 98° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04001416 |
|---|
| Source dataset | uspto-grants-1977_01 |
|---|
| ORD ID | ord-33f89bae904a43afada2cd29db801472 |
|---|
| Source note | uspto-grants-1977_01 |
|---|
