Hydrochloric Acid → HCID 86734364, compound

Participants

Reaction Steps

A mixture of 9,9-bis(2'-chloroethyl)thioxanthene (3.4 g.) and benzylamine (10 ml.) is heated under reflux for 2 hours, cooled diluted with water (100 ml.) and acidified with concentrated hydrochloric acid. The liquid is decanted from the residual gum which is triturated with water (200 ml.) when it solidifies. The solid is crystallised from ethanol to give 1'-benzylthioxanthene-9-spiro-4'-piperidine, m.p. 248° C. Addition of ether to the ethanolic filtrate remaining after removal, by filtration, of the base, yields 1' -benzylthioxanthene-9-spiro-4'-piperidine hydrochloride, m.p. 263°-266° C.

Provenance & Evidence