反应详情

To a stirred solution of 1'-benzylthioxanthene-9-spiro-4'-piperidine (2 g.) in methylene chloride (25 ml.) is added dropwise a solution of phenyl chloroformate (0.88 g.) in methylene chloride (15 ml.) at room temperature during 10 minutes. Stirring is continued for 18 hours, the methylene chloride is shaken with 1.ON sodium hydroxide solution, washed with water and dried (Na2SO4). The solution is filtered, the solvent evaporated and the residual oily product is crystallised from ethanol to give 1'-phenoxycarbonyl-thioxanthene-9-spiro-4'-piperidine, m.p. 149°-151° C.

1. washwashed with water
2. dry with materialdried (Na2SO4)
3. filtrationThe solution is filtered
4. customthe solvent evaporated
5. customthe residual oily product is crystallised from ethanol