Sodium Hydroxide → HCID 86734368, compound

Participants

Reaction Conditions

Reaction Steps

To a melt of pyridine hydrochloride (19 g.) at 160° C. is added 4-ethoxy-1'-methylthioxanthene-9-spiro-4'-piperidine (1.3 g.). The stirred mixture is heated to 210° C. for 30 minutes and then cooled, diluted with water and made alkaline with aqueous sodium hydroxide solution. A small amount of solid material is removed by filtration and the filtrate is acidified with concentrated hydrochloric acid followed by neutralisation with sodium bicarbonate and extraction with chloroform. The chloroform extract is evaporated to dryness and the residual yellow gum crystallised from aqueous ethanol to give 4-hydroxy-1'-methylthioxanthene-9-spiro-4'-piperidine, m.p. 180°-182° C.

Provenance & Evidence