Sodium Hydroxide → HCID 86734376, compound

HRID 1414538Notes

Reaction equation

HRID 1414538 reaction equation
Cl.[CH3:2][O:3][C:4]1[C:9]2[S:10][C:11]3[C:16]([C:17]4([CH2:22][CH2:21][NH:20][CH2:19][CH2:18]4)[C:8]=2[CH:7]=[CH:6][CH:5]=1)=[CH:15][CH:14]=[CH:13][CH:12]=3.[OH-].[Na+]>C(O)C.O>[CH3:2][O:3][C:4]1[C:9]2[S:10][C:11]3[C:16]([C:17]4([CH2:22][CH2:21][NH:20][CH2:19][CH2:18]4)[C:8]=2[CH:7]=[CH:6][CH:5]=1)=[CH:15][CH:14]=[CH:13][CH:12]=3

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 86734377HCID 86734377, compound

Product 1

HCID 86734376HCID 86734376, compoundYield 84.2%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 4-methoxythioxanthene-9-spiro-4'-piperidine hydrochloride (2.0 g.) in ethanol (5 ml.) is treated with 2N--NaOH solution (5 ml.), diluted with water (50 ml.) and extracted with ether (3 × 50 ml.). The combined ether extracts are washed with brine, dried over MgSO4 and the solvent evaporated in vacuo to give 4-methoxythioxanthene-9-spiro-4'-piperidine (1.5 g.).

Workup

  1. extractionextracted with ether (3 × 50 ml.)
  2. washThe combined ether extracts are washed with brine
  3. dry with materialdried over MgSO4
  4. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-2b3a82d62baa40e6ac8e05d76043d965
Source dataset
uspto-grants-1977_01
Patent number
US04001418

Reaction notes

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