Acetic Anhydride → HCID 14570271, compound

HRID 1414554Notes

Reaction equation

HRID 1414554 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([NH2:21])[C:15]=3[O:14][C:13]3[C:8]2=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH2:4][CH2:3]1.[C:22](OC(=O)C)(=[O:24])[CH3:23]>CCOCC>[CH3:1][N:2]1[CH2:3][CH2:4][C:5]2([C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([NH:21][C:22](=[O:24])[CH3:23])[C:15]=3[O:14][C:13]3[C:8]2=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 14570270HCID 14570270, compound

Product 1

HCID 14570271HCID 14570271, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 1'-methyl-4-aminoxanthene-9-spiro-4'-piperidine (0.06 g.) and acetic anhydride (0.5 ml.) in ether (20 ml.) is stirred at room temperature for 0.5 hour. The ether solution is washed with saturated sodium carbonate solution and water, dried with MgSO4 and the ether evaporated to give a gummy residue. The residue is crystallised from hexane to give 1'-methyl-4-acetamidoxanthene-9-spiro-4'-piperidine, m.p. 176°-178° C.

Workup

  1. washThe ether solution is washed with saturated sodium carbonate solution and water
  2. dry with materialdried with MgSO4
  3. customthe ether evaporated
  4. customto give a gummy residue
  5. customThe residue is crystallised from hexane

Sources & evidence

ORD record
ord-e04f2f6cf1e64c57be32ea23914fd429
Source dataset
uspto-grants-1977_01
Patent number
US04001419

Reaction notes

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