Mechlorethamine → HCID 70578263, compound

HRID 1414566Notes

Reaction equation

HRID 1414566 reaction equation
[CH2:1]([O:8][C:9]1[CH:22]=[CH:21][CH:20]=[C:19]2[C:10]=1[O:11][C:12]1[CH:13]=[C:14]([O:23][CH3:24])[CH:15]=[CH:16][C:17]=1[CH2:18]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:25][N:26]([CH2:30][CH2:31]Cl)[CH2:27][CH2:28][Cl:29]>>[ClH:29].[CH2:1]([O:8][C:9]1[C:10]2[O:11][C:12]3[C:17]([C:18]4([CH2:31][CH2:30][N:26]([CH3:25])[CH2:27][CH2:28]4)[C:19]=2[CH:20]=[CH:21][CH:22]=1)=[CH:16][CH:15]=[C:14]([O:23][CH3:24])[CH:13]=3)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 4033MechlorethamineHCID 23460504HCID 23460504, compound

Product 1

HCID 70578263HCID 70578263, compound

Procedure

5-Benzyloxy-3-methoxyxanthene is reacted with N-methyldi-(2-chloroethyl)amine using the method described in Example 1 to give 4-benzyloxy-6-methoxy-1'-methylxanthene-9-spiro-4'-piperidine hydrochloride which is used without further purification.

Sources & evidence

ORD record
ord-8d645ca7f79e4718a9ab6eafd9676cbd
Source dataset
uspto-grants-1977_01
Patent number
US04001419

Reaction notes

Loading…