反应详情

This example illustrates methods according to the invention of converting the compounds of formula II to the corresponding compounds of formula I of the invention. In this example, 350 mg. of 1,2-epoxy-3-(5-4'-methylhexylaminocarbonylthiazol -2-oxy)-propane is dissolved in 6 ml. of anhydrous ethanol saturated with ammonia and allowed to stand at room temperature for 20 hours. The mixture is then evaporated to remove ethanol and the resulting residue purified by thin-layer chromatography on preparative silica plates using a developing system of 1% triethylamine, 1.5% methanol and the remainder ethyl acetate, yielding 1-amino- 3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-propanol.

1. customThe mixture is then evaporated
2. customto remove ethanol
3. customthe resulting residue purified by thin-layer chromatography on preparative silica plates