Pyridinium chloride → 2-p-Hydroxyphenyl-3-p-methylbenzoylbenzofuran

Participants

Reaction Steps

2-p-Methoxyphenyl-3-p-methylbenzoylbenzofuran (4.9 g., 0.014 mol.) was combined with 50 g. of freshly distilled pyridine hydrochloride and the mixture was heated at 180°-190° for 4.5 hours. The hot mixture was poured with stirring onto an ice-5% aqueous hydrochloric acid mixture and the precipitate formed was extracted into ether. The ether solution was dried (MgSO4) and concentrated under reduced pressure to give 2-p-hydroxyphenyl-3-p-methylbenzoylbenzofuran.

Provenance & Evidence