Isopropylamine → HCID 21487924, compound

HRID 1414620Notes

Reaction equation

HRID 1414620 reaction equation
[C:1]([C:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[O:11][C:10]=1[C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH:26]2[O:28][CH2:27]2)=[CH:20][CH:19]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:29]([NH2:32])([CH3:31])[CH3:30]>>[C:1]([C:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[O:11][C:10]=1[C:18]1[CH:19]=[CH:20][C:21]([O:24][CH2:25][CH:26]([OH:28])[CH2:27][NH:32][CH:29]([CH3:31])[CH3:30])=[CH:22][CH:23]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 21487960HCID 21487960, compound

Product 1

HCID 21487924HCID 21487924, compound

Procedure

3-Benzoyl-2-[4'-(2,3-epoxypropoxy)phenyl]benzofuran (1.9 g., 5.2 mmol.) was dissolved in 30 ml. of freshly distilled isopropylamine and the mixture was heated in a stainless steel pressure bomb at 100° for 4.5 hours. The contents of the bomb were concentrated under reduced pressure to give the title compound. The title compound was dissolved in ether and an ethereal solution of hydrochloric acid was added to precipitate the corresponding hydrochloride salt, m.p. 53°-59°.

Workup

  1. concentrationThe contents of the bomb were concentrated under reduced pressure

Sources & evidence

ORD record
ord-a6c6f7ef136d48d593f4261aab6050bf
Source dataset
uspto-grants-1977_01
Patent number
US04001426

Reaction notes

Loading…