Isopropylamine → HCID 21487959, compound

HRID 1414623Notes

Reaction equation

ClC1C=C(C=CC=1)C(C1C2C=CC=CC=2OC=1C1C=CC(O)=CC=1)=O.C(C1OC1)Br.[Cl:31][C:32]1[CH:33]=[C:34]([CH:57]=[CH:58][CH:59]=1)[C:35]([C:37]1[C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][C:40]=2[O:39][C:38]=1[C:46]1[CH:51]=[CH:50][C:49]([O:52][CH2:53][CH:54]2[O:56][CH2:55]2)=[CH:48][CH:47]=1)=[O:36].[CH:60]([NH2:63])([CH3:62])[CH3:61]>>[Cl:31][C:32]1[CH:33]=[C:34]([CH:57]=[CH:58][CH:59]=1)[C:35]([C:37]1[C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][C:40]=2[O:39][C:38]=1[C:46]1[CH:51]=[CH:50][C:49]([O:52][CH2:53][CH:54]([OH:56])[CH2:55][NH:63][CH:60]([CH3:62])[CH3:61])=[CH:48][CH:47]=1)=[O:36]

Participants

Reactant 4

HCID 6363Isopropylamine

HCID 18430Epibromohydrin

HCID 21487958HCID 21487958, compound

HCID 53761844(3-Chlorophenyl)[2-(4-hydroxyphenyl)-1-benzofuran-3-yl]methanone

Product 1

HCID 21487959HCID 21487959, compound

Procedure

Treatment of 3-m-chlorobenzoyl-2-p-hydroxyphenylbenzofuran with epibromohydrin as described in Example 26 followed by reaction of the 3-(3'-chlorobenzoyl)-2-[4'-(2,3-epoxypropoxy)phenyl]benzofuran with isopropylamine as described in Example 25 gave the title compound.

Sources & evidence

ORD record: ord-a65b480c8f1e421e8ee3c738e18df069
Source dataset: uspto-grants-1977_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04001426

Reaction notes

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