HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 2-benzyl-2,11-dihydro-3H-s-triazolo[3,4-b][3]benzazepin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,11-dihydro-3H-s-triazolo[3,4-b][3]benzazepin-3-one | HCID 13066760 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-benzyl-2,11-dihydro-3H-s-triazolo[3,4-b][3]benzazepin-3-one | HCID 13066762 | — |
Reaction Steps
To a solution of 20 parts of 2,11-dihydro-3H-s-triazolo[3,4-b][3]benzazepin-3-one in 300 volume parts of dimethylformamide is added 5.5 parts of a sodium hydride (55%) dispersion in mineral oil under stirring. To the mixture is added 13 volume parts of benzyl bromide dropwise. After stirring for 1 hour, the crystals are collected by filtration to give 2-benzyl-2,11-dihydro-3H-s-triazolo[3,4-b][3]benzazepin-3-one as crystals. Recrystallization from ethanol gives colorless plates melting at 133° - 134° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002638 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-92cafc83b87b4653aea78cd60ae62566 |
| Source note | uspto-grants-1977_01 |