HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-{4-[(Methoxymethyl)sulfanyl]-2-nitrophenyl}acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Chloromethyl Methyl Ether | HCID 7864 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Thiocyanic acid, 4-(acetylamino)-3-nitrophenyl ester | HCID 8180927 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-{4-[(Methoxymethyl)sulfanyl]-2-nitrophenyl}acetamide | HCID 20362834 | — |
Reaction Steps
2.37 G. of 1-acetamido-2-nitro-4-thiocyanatobenzene in 10 ml. dimethylformamide is treated at 20°-25° C under nitrogen, with 0.38 g. of sodium borohydride. After 1 hour 1.6 ml. of chloromethyl methyl ether is added, and the mixture kept at 20°-30° C for a further three hours. Water is then added and the product filtered off. Recrystallization from cyclohexane gives 1-acetamido-2-nitro-4-methoxymethylthiobenzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002640 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-86d2e3e52c4a46368ee081f6c78af3c7 |
| Source note | uspto-grants-1977_01 |