HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-{[(Methylsulfanyl)methyl]sulfanyl}-2-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Chloromethyl methyl sulfide | HCID 16916 | — |
| Reactant | 4-Amino-3-nitrophenyl thiocyanate | HCID 104677 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-{[(Methylsulfanyl)methyl]sulfanyl}-2-nitroaniline | HCID 20362824 | — |
Reaction Steps
5.85 G. 1-amino-2-nitro-4-thiocyanatobenzene is treated in 20 ml. dimethylformamide under nitrogen at 20°-25° C. with 1.14 g. sodium borohydride. After 1 hour 10 ml. of methylthiomethylchloride is added and the mixture stirred overnight, diluted with water and extracted with chloroform. The dried chloroform solution is passed through a silica gel column, then evaporated to dryness leaving 1-amino-2-nitro-4-methylthiomethylthiobenzene as a red solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002640 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-ca854bd842ce48a2a1da3fc3971b8b16 |
| Source note | uspto-grants-1977_01 |