HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-[(Ethoxymethyl)sulfanyl]-2-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Chloromethyl ethyl ether | HCID 18523 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Amino-4-nitrobenzene-1-thiol | HCID 21318022 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-[(Ethoxymethyl)sulfanyl]-2-nitroaniline | HCID 20371200 | — |
Reaction Steps
A solution of 3.4 g of 2-nitro-5-mercaptoaniline in 20 ml. of DMF is treated with 0.5 g. of 100% sodium hydride, and 2.2 g. of chloromethyl-ethyl ether is added to the solution. After 30 minutes at 20-25° C, the solution is diluted with water and extracted with chloroform. Removal of the chloroform leaves 2-nitro-5-(ethoxymethylthio) aniline as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002640 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-2eeb1ac5f8834c57b3190be9242cfcf5 |
| Source note | uspto-grants-1977_01 |