2-Pyridinecarboxaldehyde → HCID 272148, compound

Participants

Reaction Steps

A mixture of oxindole (37.5 g, 0.28 mole), pyridine2-carboxaldehyde (31.8 g, 0.29 mole) and pyrrolidine (21 ml) in 90 ml of methanol is heated on a steam bath. Within a short time an exothermic reaction occurs, resulting in the deposition of a thick solid mass. The solids are collected, washed with methanol and recrystallized from methanol to give 52.5 g of product: m.p. 204°-205°.

Provenance & Evidence