Sodium Hydroxide → HCID 21484122, compound

Participants

Reaction Steps

To a solution consisting of 15.9 grams of 4-chloro-2-(3-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3 (2H)-one prepared as in example 2, 120 grams of ethanol and 5 grams of 50 percent sodium hydroxide in a pressure reactor, 1 gram of 5 percent Palladium on carbon is added and the mixture is hydrogenated at a pressure of about 15 pounds per square inch for one hour at room temperature. The resulting product is then filtered and washed with 30 grams of warm ethanol, after which the filtrate is concentrated under reduced 3 pressure. The resulting product is dissolved in 250 grams of chloroform and washed several times with water. The chloroform layer is concentrated under reduced pressure, and the resulting solid is crystallized from benzene to yield 2-(3-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H)-one, (m.p. 125° to 127° C).

Provenance & Evidence