6-m-Methoxyphenylhex-1-en-3-one → 2-Isopropyl-2-(6-m-methoxyphenyl-3-oxohexyl)cyclopentane-1,3-dione
Reaction equation
C(N(CC)[CH2:4][CH2:5][C:6](=[O:18])[CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=1)C.COC1C=C(CCCC(=O)C=C)C=CC=1.[CH:36]([CH:39]1[C:43](=[O:44])[CH2:42][CH2:41][C:40]1=[O:45])([CH3:38])[CH3:37]>>[CH:36]([C:39]1([CH2:4][CH2:5][C:6](=[O:18])[CH2:7][CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=2)[C:43](=[O:44])[CH2:42][CH2:41][C:40]1=[O:45])([CH3:38])[CH3:37]Participants
4
Procedure
Condense a mixture (6 g) of 1-diethylamino-6-(m-methoxyphenyl)hexan-3-one and 6-(m-methoxyphenyl)hex-1-en-3-one with 2-isopropylcyclopentane-1,3-dione (3 g) using a procedure similar to that described for the condensation of the 2-ethyl compound. Obtain the corresponding triketone, 2-isopropyl-2-(6-m-methoxyphenyl-3-oxohexyl)cyclopentane-1,3-dione (7.2 g) as an uncrystallizable gum.
Sources & evidence
- ORD record
- ord-0d6bbf54b4e44dd8a94d768921fe6eb0
- Source dataset
- uspto-grants-1977_01
- Patent number
- US04002746
Reaction notes
Loading…