HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (17Beta)-13-Ethyl-3-methoxygona-2,5(10)-dien-17-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | (17beta)-13-Ethyl-3-methoxygona-1,3,5(10)-trien-17-ol | HCID 66432 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1-Methoxy-2-propanol | HCID 7900 | — |
| Product | (17Beta)-13-Ethyl-3-methoxygona-2,5(10)-dien-17-ol | HCID 101950 | — |
Reaction Steps
To 13β-ethyl-3-methoxy-gona-1,3,5(10)-trien-17β-ol (1.0 g.) in 1-methoxypropan-2-ol (100 cc.) add liquid ammonia (200 cc.), followed by lithium metal (1.2 g.) in small pieces with stirring. After discharge of the blue color add an excess of ammonium chloride, followed by water; filter off the crude 13β-ethyl-3-methoxy-gona-2,5(10)-dien-17β-ol and dry, m.p. 98°-104°. No selective ultra-violet absorption beyond 220 mμ; infrared absorption peaks at 3.03, 5.92, 6.01 μ.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002746 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-249c6b9f577f4c5db6a225781351a3af |
| Source note | uspto-grants-1977_01 |