HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 68144537, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | HCID 68143773 | HCID 68143773 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68144537 | HCID 68144537 | 99.4% |
Reaction Steps
Add liquid ammonia (100 cc.) to 13β-isopropyl-3-methoxy-gona-1,3,5(10)-trien-17β-ol (0.5 g.) in tetrahydrofuran (50 cc.) followed by lithium metal (0.5 g.), and stir the solution for 10 minutes. Then add ethanol (6 cc.) dropwise. When the blue color is discharged, add water and extract the product with ether. Evaporate the washed and dried extracts to give crude 13β-isopropyl -3-methoxy-gona-2,5(10)-dien-17β-ol (0.5 g.) as colorless gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002746 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-261bb8ced79e4ee2850997d166c0f48f |
| Source note | uspto-grants-1977_01 |