HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Cyclopentylpropionyl chloride → 13beta-Ethyl-17beta-(3-cyclopentylpropionoxy)-gon-4-en-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Cyclopentylpropionyl chloride | HCID 66039 | — |
| Reactant | Gon-4-en-3-one, 13-ethyl-17-hydroxy-, (17beta)-(+-)- | HCID 10039774 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 13beta-Ethyl-17beta-(3-cyclopentylpropionoxy)-gon-4-en-3-one | HCID 22790393 | — |
Reaction Steps
Add 3-cyclopentylpropionyl chloride (2 g.) in benzene (6 cc.) to 13β-ethyl-17β-hydroxy-gon-4-en-3-one (2 g.) in pyridine (6 cc.) at -15°. Keep the mixture at -10° for 17 hours, work up and recrystallize the product from methanol to give the title compound, m.p. 88°- 89°; ultraviolet absorption peak at 241 mμ (ε17,000); infrared absorption peaks at 5.80, 6.00, 6.18 μ.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002746 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-164824d9a1194464a3c607207f0c0af7 |
| Source note | uspto-grants-1977_01 |