huagongshe.com
HRID1415018

反应详情

EQUATION

反应方程式

HRID 1415018 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)CCc1ccccc1
HCID64801

Benzenepropanoyl chloride

C9H9ClO

结构：CCC[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@H]2O
HCID68143321

未命名化合物

PRODUCTS

生成物

1
结构：CCC[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@H]2OC(=O)CCc1ccccc1
HCID22790420

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：c1ccccc1
溶剂HCID241

Benzene

C6H6

结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

Add 3-phenylpropionyl chloride (2.9 g.) in benzene (10 cc.) to 13β-propyl-17β-hydroxy-gon-4-en-3-one (2.5 g.) in pyridine at -10°. Pour the mixture into ice water and extract with benzene-ether. Wash, dry and evaporate the extracts to a gum and purify by chromatography upon Florex. Recrystallize from ethyl acetate-hexane to obtain the title compound, m.p. 104°-108°. Ultraviolet absorption peak at 240 mμ (ε16,000); infrared absorption peaks at 5.76, 6.00 μ.

WORKUP

后处理

  1. extractionextract with benzene-ether
  2. washWash
  3. customdry
  4. customevaporate the extracts to a gum
  5. custompurify by chromatography upon Florex
  6. customRecrystallize from ethyl acetate-hexane