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HRID1415032

反应详情

EQUATION

反应方程式

HRID 1415032 的结构方程式

REACTANTS

反应物

4
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：O
HCID962

Water

H2O

结构：[BH4-].[Na+]
HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

结构：COc1ccc2c(c1)CCC1=C2CC[C@]2(C)C(=O)CC[C@@H]12
HCID11055125

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc2c(c1)CCC1=C2CC[C@]2(C)[C@@H](O)CC[C@@H]12
HCID11055206

未命名化合物

收率 93.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Add sodium borohydride (8.5 g) to 3-methoxyestra-1,3,5(10),8-tetraen-17-one (40 g) in ethanol (500 ml) and reflux the mixture for 90 minutes. Acidify the cooled solution with acetic acid, add water and extract with benzene. Wash, dry and evaporate the organic extract to obtain dl-3-methoxyestra-1,3,5(10),8-tetraen-17β-ol (37.5 g), m.p. 130°-133°; ultraviolet absorption peak at 280 mμ(ε16,100); infrared maxima at 3.1 μ, 3.58 μ, 6.25 μ, 6.4 μ, 6.7 μ.

WORKUP

后处理

  1. temperaturereflux the mixture for 90 minutes
  2. extractionextract with benzene
  3. washWash
  4. customdry
  5. customevaporate the
  6. extractionorganic extract