HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86733489, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 13-Ethyl-3-methoxy-17alpha-ethynyl-17-hydroxy-6-methylgona-2,5(10)-diene | HCID 86733488 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86733489 | HCID 86733489 | 17.9% |
Reaction Steps
Stir dl-13-ethyl-3-methoxy-17α-ethynyl-17-hydroxy-6-methylgona-2,5(10)-diene (3.5 g) in methanol (90 cc) containing hydrochloric acid (60 cc) and water (4.0 ml) under nitrogen for 1 hour. Isolate the crude product, chromatograph on Florex (150 g) and recrystallize from ethyl acetate-hexane to obtain the title compound (0.60 g), m.p. 148°-151°, λmax. CHCl3 2.55 μ, 3.05 μ, 6.01 μ; λmax. EtOH 240 mμ (ε15,100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002746 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-8389fb11caad46c88e8e4a6b88fd34d9 |
| Source note | uspto-grants-1977_01 |