HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 13-Ethyl-17beta-hydroxy-6alpha-methylgon-4-en-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 68144451 | HCID 68144451 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 13-Ethyl-17beta-hydroxy-6alpha-methylgon-4-en-3-one | HCID 68144548 | 31.4% |
Reaction Steps
Stir dl-3-methoxy-17β-hydroxy-6-methyl-13-ethylgona-2,5(10)-diene (1.0 g) in methanol (54 cc) containing concentrated hydrochloric acid (3.6 cc) and water (2.4 cc) under nitrogen for 1.5 hours. Pour into brine, extract with ether and isolate the crude product. Chromatograph on Grade I neutral alumina (50 g) and recrystallize from ether-hexane to obtain the title compound (0.30 g), m.p. 127°-130°, λ max. KBr 2.98 μ, 6.03 μ; λmax. EtOH 240 mμ (ε16,500).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04002746 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-366cf5ac5bf54fd482ca521e94ec47df |
| Source note | uspto-grants-1977_01 |